Showing posts with label epigenetics. Show all posts
Showing posts with label epigenetics. Show all posts

Monday, February 21, 2011

I CHOSE THIS WAY

(Photo by JEB)

London cabbies have to acquire something called “The Knowledge” in order to be licensed. It takes a year of intensive training and study. London’s inner byways were designed for pedestrians, not vehicles. In addition, to keep down congestion, the maze is rife with one-way routes and roundabouts. Cabbies have to know not just the streets but also the businesses that line them. It’s a daunting feat of memory.

So, several years ago, they were a natural population for brain study: Did cabbies experience a quantifiable change in their hippocampi, the section of the brain that is believed to reflect memory, especially spatial memory? The scientists were foresighted enough to scan the brains of those who intended to become cabbies, pre-study, as well as those beginning their careers and those with years of experience, in addition to a control group of non-cabbies.

The results were striking. The hippocampi of cabbies altered with the inception training and became more markedly different the longer they plied their trade. In addition, the change was somewhat permanent: Brain architecture remained changed after they retired from driving.

So, are cabbies “born that way”? Is it possible that those with enhanced hippocampi somehow magically find their way into cab driving? Or is the more likely, rational explanation that our brains are fantastically plastic, our best evolutionary edge, and physical structure changes in response to persistent behavior and acculturation?

What if being a cabbie was considered immoral by the dominant intolerant religion? Would there be a subgroup of cabbies arguing that, in fact, they had been “born this way” and therefore please please don’t hate us, it’s not fair. (Ignoring the fact that almost all oppression is based on physical discrimination or circumstances of birth and rearing over which the target group has no control – but that truth has never mitigated against oppression, not in the long historical view.)

Gender is a construct and a choice. So is class, race, religion, and sexuality. It’s a choice many of us make so early that it feels like a state of birth. It can be a choice of going along with extreme cultural pressure from the adults we depend on for survival, or it can be a choice of resistance. Either way, we deserve the empowerment that would accrue to us from claiming it as a choice – and demanding respect for ANY such choice, whether it’s the popular one or not.

I have yet to speak honestly with a straight person who did not heroically resist gender and sexuality boxes in some way as a child, fighting for a wider horizon of expression. We ALL have photographs that reveal such resistance. Why do we fence ourselves away from this superlative group of allies: The entirety of humanity.

Our brains are the result of human culture as much as they are the creators of it. It’s a constant give and take. I want to see little children singing songs that exalt the power of “I CHOSE this way”, and adults celebrating them for it.

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Sunday, March 14, 2010

STEPPING OUT OF THE FRAME


I have a geek question in search of a serious answer or a fresh theory: I just read this article at Eureka! Science News about how the genome of an entire family has been sequenced to track how genetic mutations are handed on. The article states "Scientists long had estimated that each parent passes 75 gene mutations to their children." However, the actual rate of passing on was less than half of what had been estimated -- "By comparing the parents' DNA sequences to those of their children, the researchers estimated with a high degree of certainty that each parent passes 30 mutations — for a total of 60 — to their offspring."

My question is, why was the erroneous estimate so high to begin with? What were they observing that caused them to attribute a passing on of mutations at this level? And if the mutations are present but not being transmitted via our parents' DNA (which seems likely), then what IS causing the mutations?


I'm theorizing it is genetic reconfiguration that is the result of environment in early development. Cultural biological mutation, a la epigenetics. Which biological determinists and essentialists of all stripes do NOT want to admit is the case -- especially all those among us obsessed with "masculinity" as if it has authentic biological reality, instead of being a pathological cultural construct in the midst of epic fail. I am as interested in hearing "examinations of masculinity" as I am in hearing about exploring white supremacy -- i.e., it has shot its wad and we can't afford to waste any more time pretending it has value to impart. Yes, my generation looked at "femininity" which had been crammed down our throats (sometimes literally) as part of girl conditioning, but we quickly understood it was a bogus binary and instead began focusing on what was HUMAN -- and reclaiming humanity for women.

I feel this morning as if we have lost an entire generation to the rabbithole of feminist denial and a lopsided, desperate clutch at keeping the gender binary alive through the pretense of "subverting" it.

The silver lining is that money has been poured into scientific studies which hope to bolster biological determinism, and the vast majority of them (except for the tiny ones done on selected populations of adults) keep proving that culture and environment are the major factors in determining "identity". Truth will out, even if it is funded by the boys (and boy fetishists) who want to prove their definition of boy is triumphant.


NOTE: Here's another recent article from The New York Times, Human Culture Plays A Role In Natural Selection, which states that genetic adaptation to sustained cultural change "works more quickly than other selective forces, 'leading some practitioners to argue that gene-culture co-evolution could be the dominant mode of human evolution'". Yep.



[Cross-posted at Group News Blog.]

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Tuesday, May 13, 2008

TWO IMPORTANT STORIES ABOUT AFRICA

(Liberia, filming for Communication for Change, photo by Eve A. Lotter)

The Utne Reader has a good article up, Through Their Eyes, about how refugee women who are assaulted (sexually and otherwise) in West Africa are making videos expressing what it looks like through the eyes of the victims. I'm posting this to encourage you to donate what you can to the non-profits who are sponsoring this project and the community viewings/speak-outs afterward, American Refugee Committee International (ARC) and Communication for Change. Woman-created videos are also being made about forced marriage and wife beating.

But I also want to take this opportunity to comment on the language used in writing this article and how it contributes to dilution of feminism and clear thinking about what is really going on. The tag at the top reads "Victims of gender-based violence fight back with video" and the lead-in states "The crime is all too familiar for many women and girls around the world, especially those living in refugee camps where gender-based violence has become endemic: Rape is a weapon of war, forced sex a currency exchanged for food or safe passage."


But this is not, strictly speaking, gender-based violence. It's woman-hating. It's ONLY aimed against women and girls, not against a generic "gender". I mean, the corollary would be to sanitize lynching by referring to it as "race-based violence" instead of community murder of black people.

I believe this semantic shift is underway to make discussion of crimes against WOMEN somehow more palatable to the mainstream, less feminist and more "gender-studies" friendly: For all those who have difficulty facing the fact that sexism is second-class status and hatred of WOMEN AND GIRLS (and anyone else who can incidentally be shoe-horned into the NOT-MAN category.) "Gender-based" should be reserved for those statistically rare instances when the oppression is clearly being aimed against all "not-men", instead of specifically targeting women and girls. The conflation of terms does no justice to the different expression of oppressions as it is experienced by different targets. Those of us in the belly of the beast deserve to not have our struggles lumped together into academically polished and distancing language.


Recommended reading: Rape in Liberia at Womanist Musings


(From the Middle Passage drawings by Tom Feeling)

A couple of weeks ago, there was a fascinating article in the Boston Globe online about new research from a Harvard economist which "suggests that Africa's economic woes may have their roots in the slave trade" (hat tip to Jesse Wendel of Group News Blog for sending this my way). This is not an original idea -- the theory has been around for a long time. But Nathan Nunn has created innovative (and still untested) measures to verify his argument "that the African countries with the biggest slave exports are by and large the countries with the lowest incomes now (based on per capita gross domestic product in 2000). That relationship, he contends, is no coincidence. One actually helped to cause the other."

The article, Shackled To The Past, by Francie Latour, is detailed enough that you need to go read it yourself.

However, I want to address a couple of ideas within it. One section reads:

"Nunn's research also comes at a time when the most fervent calls for reparations have come and gone, but when international calls for Western apologies for slavery still draw attention. The United States has never apologized for slavery, although five states - Virginia, Maryland, Alabama, North Carolina, and New Jersey - have done so recently, and Congress is poised to consider a resolution of apology this year. With much of the world's trade policy heavily skewed to the West's advantage and Africa's disadvantage, some say apologies carry little if any value. In any case, it remains to be seen whether the United States will ever face the role it played in one of history's worst crimes."

...

"The echoes across time are fascinating, and seem undeniable. But many practitioners say that ultimately, looking at Africa's problems through the lens of slavery is self-defeating. Calestous Juma, a native of Kenya and one of the most influential voices on African economic development, falls squarely into this camp.

'The legacy of slavery cannot be denied, but if you push the argument too far, it becomes a fatalistic argument," said Juma, a professor at Harvard's Kennedy School of Government. 'Because you start to say, "Well, what can we really do? We can't undo the past, and therefore, Africa will always remain poor."'


I've thought about the idea of reparations and apology from different angles for decades now. In the 1980s, I dated a woman who was active in the African People's Socialist Party. Their platform then, and now, included reparations for African slavery in this country. While I was behind it in principle (and, I have to say, most of the other planks in their platform), I didn't think it was a realistic demand and that its quality of being "far-fetched" would detract from the other goals they were pursuing.

I've changed my mind since then. To begin with, the labeling of a goal as "far-fetched" is always soaked in cultural and target versus non-target group assumptions. Given my radicalism on so many other issues, I think it's safe to say my willingness to see reparations as "out there" arose from racism more than sudden rationality.

To illustrate my point, other reparations movements (such as Jews claiming damages from the Holocaust) meet with far more public (i.e., white people) acceptance and respectful airplay. However, the turd in the punchbowl is that the wealth of the United States is utterly founded on theft of land and labor. There is a prevailing myth to the contrary, especially among white people, that America's "greatness" is the product of hard labor. Labor by men, this means. White men. The work of women is taken for granted, and the resources of others is considered the property of white men by manifest destiny and Christian-backed racial superiority.

Relinquishing this myth to reality would do more than flood the foundations of white supremacy and woman-hating. It would also remove the chief delusion propping up white working class compliance with rule by the power elite: The fantasy that their own hard work will lead to class advancement and stability. Forcing the white lower classes in this country to face the truth that their status, however shitty, is never going to change through their own efforts and, even so, they are advantaged in comparison to the people of color living around them would lead to revolution.

If we took a zen approach to undoing the past -- we can't really time travel, but we can undo the effects of the past manifested present-day -- we'd have enormous opportunity to level economic prosperity on a global level. Since America currently stands squarely in the past of this progress, anything which would address the cultural and psychological pathology supporting such obstruction could help jiggle it loose.

For this second-tier reason, then, I'm also in favor of pushing for reparations. Bringing the actual source of our economic advantage into the clear light of day would be immensely tonic for my class, and enable us to (possibly) step around the racism which keeps us doing the dirty work of standing on our sisters' and brother's necks. I can only hope.

Likewise, governmental apologies have been applauded by everyone except Republicans and their ilk. In its honest form, an apology says "I see what I did there, I feel badly for how my action hurt you, and I'm going to take steps to make sure I don't do it again." Apology is an adult skill, arising from a blend of developmental attainment and responsibility -- to others AND to self. Which explains why it is beyond the reach or comprehension of conservatives and evangelicals, but we have to not let their limitations be our lowest common denominator any longer.

The article states:

"Juma and Nunn may be working toward an eventual meeting of the minds. The Kenyan sees slavery's lasting scar as a deeply psychological one - an attack on the self-confidence of a continent, and by extension, its human potential. Until that legacy is conquered, Juma said, Africa will not advance.

"Nunn, now at work on Chapter 2, has another name for this legacy: He calls it the trust channel. He can't prove it. But using household surveys of Africans over the last seven years known as the Afrobarometer, he is finding that ethnic groups that had the most slaves taken in the past express the most difficulty trusting people within their group, and outside their group. It may be that as it ravaged populations and crippled institutions, the hunting down and handing over of their own kin also robbed them of an innate ability to trust, all the way to the present day.

"Measuring this kind of collective feeling, and correlating it to events so far in the past, will likely put Nunn right back on slippery ground. But he doesn't seem to mind. 'The idea of the transmission or evolution of trust over generations, and this being affected by these large historic events,' Nunn said, 'is definitely not mainstream in economics.'"


I was fascinated by the introduction of this word, trust. (As was Jesse, hence his recommendation to read this article.) Trust of course arises from relationship, and dysfunctional/damaging relationships erode trust backwards and forwards along the temporal plane. I think it is possible that this is perpetuated not just through conditioning and culture -- i.e., we raise our children to distrust because of a devastating betrayal in the past. I think it is possible that this erosion of trust is making its way into biological expression via epigenetics: The way in which rearing and environment (nurture) alters our very biology, either temporarily (during our lifetime) or in a more long-lasting fashion (altering the genes that get passed on).

The plasticity of our genetic expression as is currently being discovered, daily, through epigenetic study is where the hope lies in this revelation of centuries of distrust. It's a reversible condition.

But apology will be the first step in that healing. There's no way around it. It will be good for us, good for the world, good for future generations. When you write your elected representatives or speak to the powerful, I ask to you add this to your list of requests: That we learn how to apologize, and do it (on every scale) when we have transgressed. It's not enough to sing "Amazing Grace" any more (as if it ever was), marveling at that which "saved a wretch like me" but not moving emotionally to the next step. We have to reverse the Middle Passage, in whatever ways we can dream up. Wouldn't you rather live in a world which took on this task?


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Wednesday, March 26, 2008

UP TO YOU

(Vision Portal: Crocus, by Lowry Bell)

I've written before at this blog about human brain plasticity and at Maoist Orange Cake about Epigenetics and Cultural Re-Invention. I have more exciting discoveries to share with you.


Last month I watched a superb special on Nova at PBS called Ape Genius. It's introduced with "A rush of discoveries about chimps, from tool use to what they do for fun, are painting a surprising new portrait of ape minds." I've discovered it is also available online, divided into six chapters at the above link, and I've watched it all the way through again. I can't recommend it enough.

It acknowledges, rather tongue-in-cheek, our past human obsession with demarcating the DIFFERENCE between us and apes, our insecurity leaking through as apes crash one barrier after another and we move the goal-posts to keep us "winning". Even as this film does so, it makes it clear the distinction between ape intellect and our own will be the focus of this effort, but with (hopefully) more maturity:

'Congratulations: You are an ape. A "great ape," technically. Alongside us in this brainy family of animals are four other living species: chimpanzees, gorillas, orangutans, and bonobos (formerly called "pygmy chimpanzees").

'The biological gap between us and our great ape cousins is small. At last count, only 1.23 percent of our genes differ from those of chimpanzees. But mentally, the gap between us and them is a Grand Canyon.

'On an average day in the life of the human species, we file thousands of patents, post tens of thousands of Internet videos, and think countless thoughts that have never been thought before. On a good day, chimpanzees are lucky to exploit rudimentary tried-and-true techniques, such as using stone tools to crack nuts.

'Not only do we innovate more than the other great apes, we are vastly better at sharing ideas with one another. The majority of recent behavioral studies focus on information-transmission rather than invention. All of the great apes can learn new tricks by imitating a human or another ape. But only humans go one step further and routinely teach each other. Teaching may be the signature skill of our species, and researchers are now zeroing in on three particular mental talents that make it possible."

And here's where the documentary really grabs me: The three mental talents explored are "Mind-Reading", "The Triangle (as used in teaching)", and "Impulse Control". As they were described, I realized not only does this gap exist between us and apes, but within human culture, the development and value placed on these talents varies considerably, with enormous political and survival consequences. And, in my assessment, these extremely human, cooperative, advantageous traits are most under-emphasized in the conditioning we receive as white Westerners and in the conditioning we give males, particularly when cramming them into the "masculine" role.

Which begs the question: Why would we, as a species, be dampening down the most useful of our human evolutionary skills in order to pay obeisance to, say, impulsivity, mimicking without comprehension, competition over empathy and altruism, isolation and exploitation over interdependence?

(Graphic by Austin Cline)

I think we'll have to answer this question before we can reverse the trend. And, of course, part of the lesson will have to include that we have much more choice over our behavior and identities than not. We are not helpless in the grip of biology. We took another path, long ago, and it's quite possible, as a friend stated this week, we're witnessing yet another paradigm shift.

Watch it and tell me what you think.

In a related story, the New York Times just printed an article by Sandra Blakelee titled What a Rodent Can Do With a Rake in Its Paw. It begins:

"Degus are highly social, intelligent rodents native to the highlands of Chile. They adorn the openings of their burrows with piles of sticks and stones, have bubbly personalities and like to play games.

"But in a laboratory setting, degus can do much more than play hide-and-seek, according to a study in the online journal Plos One. They can learn to use tools."

The article includes a short video of a degu engaged in tool use. I could not find an independent link to this, so you'll have to go to the article link above to watch it. It goes on to say:

"While it has long been thought that tool use is a hallmark of higher intelligence, Dr. Iriki said, the brain structures that underlie such abilities may lie dormant in many animals with good hand-and-eye or paw-and-eye coordination. Training them to use tools in captivity provides insights into the plasticity of their brains, he said, and may shed light on how early humans evolved tool use in the first place.

"In the wild many animals use simple tools. Chimpanzees and crows actually create them. But an underlying question is, What changes take place in an animal brain when tool use evolves?

"To find out, Dr. Iriki initially conducted experiments with Japanese macaques, monkeys that do not tend to use tools in the wild. In the laboratory, he trained them to use a rake to reach out and retrieve their favorite treat, raisins. Later the animals learned to use a short rake to pull in a longer rake, which could then be used to fetch more distant raisins.

"As the monkeys developed these skills, their brains showed signs of gene activity in a brain region that integrates vision and touch. The same was likely to be true of the degu, Dr. Iriki said. The rodent has superb paw-and-eye coordination and a pad on its paw that can act like a thumb."

Once again, this study proves that what seems immutable -- genetic organization of a brain -- is actually quite plastic, and that genes themselves alter within an individual animal (not just through reproduction in new generations) as a response to environmental demand.

For those of us who have stepped beyond the Western rigidity of believing "God made us this way" and "Reality is concrete", we're not surprised to discover that we transform our own bodies by transforming our mind-set.

The "persistent delusion" (as I learned from Buddhism) that we all cling to was brought home to me in another way last week during a conversation with a friend. He pointed out that if you measure the wave length of blue light, it is clearly distinguishable from that of all other colored light. Ditto for yellow light, and ditto for green light. But if you shine both blue and yellow light on a surface, what we see is green. Yet if you measure the wave lengths, all that is objectively there is still just blue and yellow. The green is created within our brains: It's a perception, not a scientific property of the light.

I find liberation in this. Yes, it cuts me loose from the wharf, but there are others of us out here bobbing around in the current. All you have to do is love yourself as you are.

(from Stella Marrs)


© 2008 Maggie Jochild; hat tip to Doc and Diamante for the shared thinking

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